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Volk, Cortical inhibitory neurons and schizophrenia

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JAMA Neurol 73(12):14251432 Obrador E, Salvador R, Marchio P, Lpez-Blanch R, Jihad-Jebbar A, Rivera P, Valls SL, Banacloche S, Alccer J, Colomer N, Coronado JA (2021) Nicotinamide riboside and pterostilbene cooperatively delay motor neuron failure in ALS SOD1G93A mice

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NAD+ precursors enter cells through specific pathways and help create NAD+ through several metabolic routes: De novo synthesis pathway : The liver creates NAD+ from L-tryptophan through the kynurenine pathway Preiss-Handler pathway : This converts nicotinic acid (NA) to NAD+ NAM salvage pathway : This pathway recycles nicotinamide (NAM) back into NAD+ and serves as the main pathway for NAD+ production Gene expression data shows the salvage pathway produces 99.3% of cardiac NAD+ stores

doi: 10.7189/jogh.13.04177, 116 YangY.WangK.LiuH.QuJ.WangY.ChenP.et al